Gasoline (US, CA; ) or petrol (CW except Canada; ) (see § Etymology) is a transparent, petroleum-derived flammable liquid that is used primarily as a fuel in most spark-ignited internal combustion engines (also known as petrol engines). It consists mostly of organic compounds obtained by the fractional distillation of petroleum, enhanced with a variety of additives. On average, U.S. refineries produce, from a barrel of crude oil, about 19 to 20 gallons of gasoline; 11 to 13 gallons of distillate fuel (most of which is sold as diesel fuel); and 3 to 4 gallons of jet fuel. The product ratio depends on the processing in an oil refinery and the crude oil assay. A barrel of oil is defined as holding 42 US gallons, which is about 159 liters or 35 imperial gallons.

The characteristic of a particular gasoline blend to resist igniting too early (which causes knocking and reduces efficiency in reciprocating engines) is measured by its octane rating, which is produced in several grades. Tetraethyl lead and other lead compounds, once widely used to increase octane ratings, are no longer used except in aviation, off-road and auto-racing applications. Other chemicals are frequently added to gasoline to improve chemical stability and performance characteristics, control corrosiveness, and provide fuel system cleaning. Gasoline may contain oxygen-containing chemicals such as ethanol, MTBE, or ETBE to improve combustion.

Gasoline can enter the environment (uncombusted), both as liquid and as vapor, from leakage and handling during production, transport, and delivery (e.g., from storage tanks, from spills, etc.). As an example of efforts to control such leakage, many underground storage tanks are required to have extensive measures in place to detect and prevent such leaks. Gasoline contains known carcinogens. Burning one liter (0.26 U.S. gal) of gasoline emits about 2.3 kilograms (5.1 lb) of CO₂, a greenhouse gas, contributing to human-caused climate change.